Bio 431 - Signal Transduction Pathways

Professor Maryanne McClellan

In this seminar we explore the signal transduction pathways that coordinate cellular behaviors controlled by diffusible chemicals such as peptide growth factors, hormones and cytokines. We begin with a current review of the classical pathways activated by receptor tyrosine kinases and G protein-linked receptors. Our discussions primarily focus on literature examples of growth factor and hormone action in animals with an emphasis on the particular mechanisms which control cellular reproduction, differentiation and survival. If time permits, the evolutionary aspects of signal transduction are viewed from the comparative perspective of simple systems such as bacteria, yeast, and ethylene action in plants. Depending upon the specific interests of students making presentations, some additional topics we might investigate include the regulatory roles of parallel interacting pathways, steroid hormone action, calcium sensing and integrin signalling.

Attendance and preparation is required because there is no final exam or term paper. Each student will present two 45 minute seminars to the group. At least one of these must occur prior to the break. Topics are chosen in consultation with me, Maryanne McClellan - mcm@reed.edu. Two copies of the approved readings must be available the week preceding your presentation. It is anticipated that all students will be discussants for all papers presented to the group.

Prerequisite: Students are expected to have taken at least one previous course in animal physiology, cellular, developmental or molecular biology and must have junior or senior standing.

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