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Janis Shampay
Reed College Portland, OR 97202 Office: Biology B226 |
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Janis Shampay
Reed College Portland, OR 97202 Office: Biology B226 |
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Biology 256: Human Genetics
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Teaching Spring Semester: |
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| 1981 | B.A., Biochemistry and Molecular Biology, Northwestern University, Evanston IL | |
| 1987 | Ph.D., Molecular Biology, Univ. of California, Berkeley |
| Bio356, Genetics and Gene Regulation, is an upper division lecture-laboratory course focusing on mechanisms of eukaryotic gene regulation and the experimental approaches used to elucidate them. I offer an advanced seminar course on telomeres and telomerase, and in some years a sophomore lecture-conference course on human molecular genetics. |
My laboratory has been investigating the structure and behavior of chromosome ends, or telomeres. These specialized structures are required for chromosome stability and maintenance, yet some of their features are quite dynamic. Chromosome ends are maintained by the ribonucleoprotein, telomerase, in a regulated manner. When telomerase is absent and cells divide, telomeres erode; when telomeres reach a critical length or the structure is perturbed, the cells will either cease dividing or undergo programmed cell death. Telomere binding proteins are important to structural integrity and regulation of telomere length. In contrast to humans, Xenopus expresses abundant telomerase activity in all somatic tissues. With support from the National Science Foundation, we have identified telomere binding protein genes in Xenopus; we are perturbing these proteins in vivo and asking if they are regulated the same way as their human homologs. |
| Michael Wernick (2008) Is PinX1 a negative regulator of telomerase in Xenopus laevis? | |
| Gillian Woodruff (2008) Expression and characterization of Xenopus laevis POT1 | |
| Jayne T. Gaubatz (2007) PINX1: A Potential Telomerase Inhibitor in Xenopus laevis | |
| Angela Gibbs (2007) Tankyrase in Xenopus laevis | |
| Mikella Procopio (2007) Xenopus laevis Pot1 OB Fold Expression in E. coli and siRNA Construction | |
| Jacob Schwartzman (2007) An Attempt to Characterize the Function of a Telomere Protection Protein in Xenopus laevis | |
| Nicholas Blanchard-Wright (2006) A GFP-fusion protein with the N-terminal DNA binding domain of Xenopus laevis POT1 | |
| Clea Aguera-Arcas (2005) Cloning Xenopus laevis telomere binding protein, POT1 | |
| Tristan Victoroff (2005) Inhibit This! Attempts at a TRF1 knockdown in Xenopus laevis | |
| Nate Crumet (2004) TRF1 in Xenopus laevis may be post-transcriptionally regulated | |
| Royd Carlson (2004) Isolation of the 5' end of Xenopus tropicalis TRF1 mRNA | |
| Marisa Connell (2004) Cloning of the promoter of the Xenopus laevis telomerase catalytic subunit | |
| Althea Hayden (2003) Somatic telomerase expression in vertebrate taxa: correlations with life history variables and stability in frozen tissues |
Crumet N, Carlson RL, Drutman SB, and Shampay J. 2006. A truncated acidic domain in Xenopus TRF1. Gene 369: 20-26 [Epub Nov 23, 2005] |
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| Bousman S, Schneider G, Shampay J. 2003. Telomerase activity is widespread in adult somatic tissues of Xenopus. J. Exp. Zoolog. Part B Mol Dev Evol. 295: 82-6. | |
| Bassham, S., Beam, A., and Shampay, J. 1998. Telomere variation in Xenopus laevis. Mol. Cell. Biol. 18: 269-275. | |
| Shampay, J, Schmitt, M, and Bassham, S. 1995. A novel minisatellite at a cloned hamster telomere. Chromosoma 104: 29-38. | |
| Shampay, J, and Blackburn, EH. 1989. Tetrahymena micronuclear sequences that function as telomeres in yeast. Nucl. Acids Res. 17(8): 3247-3260. | |
| Shampay, J, and Blackburn, EH. 1988. Generation of telomere length heterogeneity in Saccharomyces cerevisiae. PNAS 85, 534-538. | |
| Shampay, J, Szostak, JW, and Blackburn, EH. 1984. DNA sequences of telomeres maintained in yeast. Nature 310: 154-157. |
| Member, Faculty for the 21st Century, Project Kaleidoscope | |
| Devoted collector of felines |
Maintained by the Reed College Biology Department
Last Modified 2/12/04
