Maryanne McClellan

Reed College
Portland, OR 97202

Office: Biology B210
(503) 777-7263
e-mail: Maryanne.McClellan@reed.edu



EDUCATION
TEACHING
RESEARCH
STUDENT THESES
POSTER PRESENTATIONS
SELECTED PUBLICATIONS


EDUCATION

Auburn University, B.S., 1971
Colorado State University, M.S., 1975
Colorado State University, Ph. D., 1979
Oregon Regional Primate Center - NIH Postdoctoral Fellow, 1980-81


TEACHING

(look in Courses folder for materials)

Bio 272 Reproductive Biology
Reproductive Biology is taught in a lecture/conference format. We focus on comparative vertebrate reproduction beginning with the cell biology of meiosis, fertilization, gamete production and the conundrum of the cost of sexual reproduction. We examine comparative modes of reproduction, sex determination, hormone action and parental investment. Small groups of students lead one conference during the semester chosen from among several suggested topics.

Bio 372 Cellular Biology
Cellular Biology is an upper division lecture/laboratory/conference course that emphasizes relationships between structure and function in cellular activities. We explore the origins of eukaryotic cells, the structure, synthesis and discrete distribution of cellular proteins and the notion that cellular energy is information. We also discuss topics such as how cells transduce energy, move, reproduce, communicate, differentiate and die. Students write take-home essays on topics I suggest in lieu of formal in class exams. The laboratory component focuses on contemporary methodology and includes a six-week independent experiment in the second quarter of the semester. In an optional, weekly evening conference, we review selected literature in preparation for essay exams.

Bio 431 Cellular Regulation
Cells transduce regulatory information from the environment via stereotypical “signal transduction” pathways. In other words, when appropriately stimulated, cells use energy to create the information for selective behavior and genome use. Using the primary literature, we explore examples of G protein-coupled receptor, steroid hormone receptor and receptor tyrosine kinase action and ask how specific cellular outcomes are achieved through signal processing and integration. Cellular Regulation is taught as a weekly 2-hour journal club for students with junior standing and a previous molecular or cellular biology course. Individual students participate in leading conferences during the semester one of which is centered on a primary research article/topic chosen by the student.

I also teach in the team-taught course Introductory Biology.

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RESEARCH

I am broadly interested in vertebrate reproduction and specifically in estrogen action. Currently, my laboratory is focused on understanding mechanisms of gene repression in response to acute estrogen treatment. Genome-wide strategies to find targets of estrogen receptor alpha (ERa) in cultured breast cancer cells have turned up a surprising number of genes whose transcription is inhibited by hormone treatment. Using some of these newly discovered ERa targets, we are studying the molecular mechanism/s of estrogen-dependent gene repression. By binding to estrogen and other environmental compounds that mimic estrogen, ERs alter the expression of particular genes during development, reproduction and disease. ER status is an important therapeutic indicator in breast cancer, and presumably the disease state results in part from aberrant gene expression.

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RECENT STUDENT THESES

» Thesis Student Slideshow

The following is a list of senior theses completed by students in my lab. To view some of these students' published abstracts go to: http://academic.reed.edu/biology/theses/

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POSTER PRESENTATIONS BY SUMMER RESEARCH STUDENTS

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PUBLICATIONS

1974 Cholesterol and bile acid turnover in miniature swine. Lipids 9:717-721. (Dupont, J, Oh, S-Y, O'Deen, L., McClellan, M.C., Lumb, W.V., Butterfield, A.B.)
1975 Subcellular compartmentalization of the luteal cell in the ovary of the dog. Cell Tissue Res 158:461-480. (Abel, J.H., McClellan, M.C., Verhage, H.G., Niswender, G.D.)
1975 Ultrastructural analysis of the granulose-luteal cell transition in the overy of the dog. Cell Tissue Res. 160:155-165. (Abel, J.H., Verhage, H.G., McClellan, M.C., Niswender, G.D.)
1975 Luteinizing hormone, progesterone and the morphological development of normal and superovulated corpora lutea in sheep. Cell Tissue Res. 164:291-307. (McClellan, M.C., Diekman, M.A., Abel, J.H., Niswender, G.D,)
1976 Effects of prostaglandins on the ovine corpus luteum: blood flow, secretion of progesterone and morphology. Biol. Reprod. 15:66-78. (Nett, T.M., McClellan, M.C., Sawyer, H.R., Diekman, M.A., Niswender, G.D.)
1977 Function of lysosomes during luteal regression in normally cycling and PGF2a-treated ewes. Biol. Reprod. 16:499-512 (McClellan, M.C., Abel, J.H., Niswender, G.D.)
1979 Secretory granules and progesterone secretion by ovine corpora lutea in vitro. Endocrinology 194:476- (Sawyer, H.R., Abel, J.H., McClellan, M.C., Schmitz, M.H. Niswender, G.D.)
1983 Estradiol synthesis by fetal monkey ovaries correlates with antral follicle formation. Biol. Reprod. 28:505-516. (Ellinwood, W.E., McClellan, M.C., Brenner, R.M., Resko, J.A.)
1984 Immunocytochemical localization of estrogen receptors in the macaque reproductive tract with monoclonal antiestrophilins. Endocrinology, 114:2002-2014. (McClellan, M.C., West, N.B., Tacha, D.E., and Brenner, R.M.,)
1986 Estrogen receptors in stromal and epithelial cells of the macaque endometrium during the luteal-follicular transition. Endocrinology, 119:2467-2475. (McClellan, M.C., West, N.B., and Brenner, R.M.)
1987 Inverse diffusions methods for data peak separation. Anal. Biochem. 167, 15-22. (Crandall, R.E., McClellan, M.C., Arch, S., Doenias, J. and Piper, R..)
1990 Estrogen receptors, progestin receptors and DNA synthesis in the macaque endometrium during the luteal-follicular transition. J. Steroid Biochem. Molec. Biol. 37:631-641. (McClellan, M.C., Rankin, S., West, N.B. and Brenner, R.M.)
1991 Endocrine and morphologic maturation of the fetal and neonatal adrenal cortex in baboons. J Clin Endo Metab 73:385-395. (Ducsay, C.A., Hess, D.L., McClellan, M.C. and Novy M.J.)
1991 Estrogen and Progestin Receptors in the Macaque Endometrium. Annals New York Acad. Sci. 622:149. (Brenner, R.M., McClellan, M.C., West, N.B., Novy, M.J., Haluska, G.J., and Sternfeld, M.D.)
1999 Regulation of proliferation and apoptosis by epidermal growth factor and protein kinase C in human ovarian surface epithelial cells. Exp Cell Res 246:471-479. (McClellan, M.C., Kievet, P., Ausperg, N. and Rodland, K.D.)
2008 Female-Specific Increase in Primordial Germ Cells Marks Sex Differentiation in Threespine Stickleback (Gasterosteus aculeatus) J Morphology 269:909-921 (Zachary R. Lewis, Maryanne C. McClellan, John H. Postlethwait, William A. Cresko, Robert H. Kaplan)

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Questions/Comments to Maryanne.McClellan@directory.reed.edu