Ronald W. McClard

Arthur F. Scott Professor of Chemistry (Biochemistry) Reed College 3203 S.E. Woodstock Blvd. Portland, OR 97202 Office: Chem 421 Phone: 503-777-7218 FAX: 503-788-6643 Email: ronald.mcclard@reed.edu

Teaching schedule

• Fall - Chem 311 - Analytical Chemistry
• Spring - Chem 392 - Metabolic Biochemistry
• Spring - Chem 394 - Biochemical Methods

Education

• B.A. 1972 Central College
• Ph.D. 1978 University of California - Los Angeles

Research Interests in Biochemistry

• Bioorganophosphorus chemistry
• Design and synthesis of enzyme modifiers and prototypes of pharmaceutical agents
• Bioorganic mechanisms
• Metabolism
• Applications of NMR spectroscopy of biochemistry.

Selected Grants & Publications

(last updated 1998)

• "Inhibitors in Nucleic Acid Biosynthesis" (Medical Research Foundation of Oregon , 3/1/95-2/28/96, $24,800).
• "Mechanistic Probes of Phosphoribosyltransferases (and Nucleoside Phosphorylase)" (National Institutes of Health 6/20/96 - 9/19/98, $109,621).

1. Stowell, M.H.B., McClard, R.W., and Yatvin, M.B. (1994) Effects of Membrane-Lipid Composition on Nascent Protein Translocation Induced by Heat and Ethanol in Escherichia Coli, J. Therm. Biol. 19, 111-122.

2. McClard, R.W. and Witte, J.F. (1994) Synthesis of the Phosphonate Analogue of Methylthioribose 1-alpha-phosphate. BioMed. Chem. Lett. 4, 1537-1538.

3. Witte, J. F., Frith, R. and McClard, R.W. (1995) A Convenient Synthesis of Ribonolactone and Other Aldonolactones, Carbohydr. Lett. 1, 123-124.

4. McClard, R.W. and Witte, J.F. (1996) C-Glycosylphosphonyl Analogs of 5-Phorphorylribose 1-alpha-diphosphate. II. The "2-Deoxy" Phosphonate Analog, Bioorg. Chem. 24 (1), 29-38.

Other Professional Activities

Served as one of four neutral scientific advisors to United States Distict Court Judge Robert E. Jones, District of Oregon, on the merit of evidence presented in the silicone breast implant litigation according to land mark application of Federal Rules of Evidence Rule 104 (involving apprx. 70 individual cases). Aug/Sept., 1996.