Instructor: Arthur Glasfeld , Chemistry 410, (503)517-7679
Meets Tues. 6:10-7:30 PM in ETC 205 (See Course Prospectus)
Remember: Final papers due at 5 PM on 12/13/07
Rae et al. (1999) Undetectable Intracellular Free Copper Science 284, 805-808.
Torres et al. (2001) Copper Stabilizes a Heterodimer of the yCCS Metallochaperone. J. Biol. Chem. 276, 38410-38416.
Molina-Heredia et al. (2006) Detoxification of superoxide without H2O2: Antioxidant activity of superoxide reductase complexed with ferrocyanide PNAS 103, 14750-14755.
Katona et al. (2007) Raman-Assisted Crystallography Reveals End-On Peroxide Intermediates in a Nonheme Iron Enzyme. Science 316, 449-453.
Stahley and Strobel (2005) Structural Evidence for a Two-Metal-Ion Mechanism of Group I Intron Splicing. Science 309, 1587-1590.
Forconi et al. (2007) Modulation of individual steps in group I intron catalysis by a peripheral metal ion. RNA 13, 1656-1667.
Baldwin et al. (2001) DNA cleavage by the EcoRV restriction endonuclease: roles of metal ions in specificity and catalysis. J. Mol Biol. 288, 87-103.
Chevalier et al. (2004) Metal-Dependent DNA Cleavage Mechanism of the I-CreI LAGLIDADG Homing Endonuclease. Biochem. 43, 14015-14026.
Outten, C. E., and O'Halloran, T. V. (2001) Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis. Science 292, 2488-2492.
Changela et al.(2003) Molecular Basis of Metal-Ion Selectivity and Zeptomolar Sensitivity by CueR Science 301, 1383-1387.
Hartwig & Lippard(1992) DNA Binding Properties of cis-sort of platin, a Metabolite of an Orally Active Platinum Anticancer Drug. J. Am. Chem. Soc. 114, 5646-5654.
Jamieson et al.(1999) Structural and Kinetic Studies of a Cisplatin-modified DNA Icosamer Binding to HMG1 Domain B J. Biol Chem. 274, 12346-12354.
Heginbotham et al.(1998) Functional reconstitution of a Prokaryotic K+ Channel, J. Gen. Phys. 111, 741
Morais-Cabral et al.(2001) Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature 414, 37.
Uversky et al. (2001) Metal-triggered Structural Transformations, Aggregation, and Fibrillation of Human alpha-Synuclein. J. Biol. Chem. 276, 44284-44296.
Payne et al. (1999) Lead Fingers: Pb2+ Binding to Structural Zinc-Binding Domains Determined Directly by Monitoring Lead-Thiolate Charge-Transfer Bands. J. Am. Chem. Soc.121, 6850-6855.
Gehring et al. (2005) Spectroscopic and Functional Determination of the Interaction of Pb2+with GATA Proteins. J. Am. Chem. Soc. 127, 3751-3759.
Martinez et al. (2003) Structure and membrane affinity of a suite of amphiphilic siderophores produced by a marine bacterium. Proc. Nat. Acad. Sci. USA 100, 3754.
Küpper et al. (2006) Photoreactivity of Iron(III)-Aerobactin: Photoproduct structure and Iron (III) Coordination. Inorg. Chem. 45, 6028.
Course introduction. Some notes on metals and biochemistry.