Week Two - Sept. 3-7, 2007

Tuesday - Secondary Structure in Proteins

Reading: 
    Lecture notes on protein secondary structure.
    Voet and Voet, Ch. 8

Literature refs: The original and an excellent review.
    Pauling et al. (1951) The Structure of Proteins: Two H-Bonded Helical Configurations of the Polypeptide Chain. Proc. Natl. Acad. Sci. USA 37, 205.
    Eisenberg (2003) The discovery of the alpha-helix and beta-sheet, the principal structural features of proteins. Proc. Natl. Acad. Sci. 100, 11207-11210.

Visuals from class:
   Animations of energy vs. dihedral angle: ethane, butane, hydroxybutane, phi and psi

Thursday - Tertiary and Quaternary Structure

Reading: 
    Voet & Voet, Chapter 8 cont.

Literature ref: Proteins without structure... Go figure.
    Tomba (2002) Intrinsically Unstructured Proteins, TIBS, 27, 527-533.