Tuesday - Crystallography and NMR
Reading:
Section 8.3A of Voet & Voet
Ch. 18 of Branden & Tooze (on reserve in library)
My notes of crystallography (pdf format)
On-line NMR pages by Horst Joachim Schirra
Judging Model Quality (NMR and xtallography) by Gale Rhodes
From the Literature: some of my favorite articles on the perils of believing what you see.
Brändén & Jones (1990) Between objectivity and subjectivity. Nature 343, 687-688. (A good warning)
Acharya & Lloyd (2005) The advantages and limitations of protein crystal structures. TIPS 26, 10-14. (A good review)
Chang et al. (2006) Retraction. Science 314, 1875. (A wake up call to the community. A lot of follow up articles/opinion pieces are listed at the bottom of this article.) Borman (2007) Structure Quality. C&ENews 85, 11 (A news article describing issues with protein structures appearing in "hot" journals.)
Thursday - Nucleic Acid Structure
Reading:
Voet & Voet, Ch. 5.1 & 5.3, 29.1-29.2
My lecture notesDNA 50th Anniversary website @ Nature
From the Literature:
Watson & Crick (1953) Molecular Structure of Nucleic Acids. Nature 171, 737.