Tuesday - Nucleic Acid Secondary Structure
Reading:
Voet & Voet, Ch. 5.1 & 5.3, 29.1-29.2
My lecture notesDNA 50th Anniversary website @ Nature
From the Literature:
Watson & Crick (1953) Molecular Structure of Nucleic Acids. Nature 171, 737.
A. Rich (2003) The double helix: a tale of two puckers. Nat. Struct. Biol. 10 247-249.
O. Kennard (1986) DNA conformation is determined by economics in the hydration of phosphate groups. Nature 324 385-388.
Thursday - RNA Structure & Function
Notes on Ligand Binding
Aptamer Review Articles:
Wilson & Szostak (1999) In Vitro Selection of Functional Nucleic Acids. Annu. Rev. Biochem. 68, 611-647 (note that reading beyond p. 622 in the article takes you beyond the scope of today's lecture).
Hermann and Patel (2000) Adaptive Recognition by Nucleic Acid Aptamers. Science 287 820-825.
Riboswitches:
Breaker Lab Website: For those seeking biological function, check out the link to the powerpoint movie on this page.
Additional Reading
Reichow & Varani (2006) RNA switches function. Nature 441, 1054-1055. (Reviews SAM riboswitch particularly)
Winkler (2005) Riboswitches and the role of non-coding RNAs in bacterial metabolic control.Curr. Op. Chem. Biol. 9, 594.602.