Tuesday - Triose Phosphate Isomerase & General Acid-Base Catalysis
Reading
Voet and Voet, Chapter 15.1.A (just the first bit), 17.2.E
My lecture notes on TIM (incomplete)
Review articles on Triose Phosphate Isomerase
J. Knowles (1991) Enzyme catalysis: not different, just better.Nature 350, 121-124.
J. Knowles(1991). To Build an Enzyme... Phil. Trans. R. Soc. Lond. B 332, 115-121.
Thursday - Cleaving RNA
Reading
Voet and Voet, Chapter 15.1.A (all of it), 15.1.C, 31.4.f,g
Optional
Ribonuclease Review: Steyaert (1997) Eur. J. Biochem. 247, 1
HDV Ribozyme & General Acid Catalysis: Strobel (2005) Nat. Chem. Biol. 1, 1
J. Doudna (2005) Ribozyme Catalysis: not different, just worse, NSMB 12, 395-402