Tuesday 11/27 - Amino acyl tRNA synthetase specificity continued

Reading

Voet and Voet - Ch. 32.1-32.2

My notes on the topic.

The Hopfield Mechanism explained.

Optional Reading

Fersht Structure and Mechanism in Protein Science pp. 235-242, 385-390,

Also - a very nice animation of ribosome action during translation.

 

Thursday 12/1 - Ribosomal Catalysis

Reading

Voet and Voet, Ch. 32.3

My notes on Translation.

A Must-See Movie

Some very good reviews

Rodnina (2006) The Ribosomal Peptidyl Tranferase. Mol. Cell 26, 311-321.

Rodnina & Wintermeyer (2001) Ribosome Fidelity TIBS 26, 124.

Steitz & Moore (2003) The Ribosome is a Ribozyme TIBS 28, 411.